Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 169

会议视频 1

年份

2023 6

2022 14

2021 5

2020 4

2019 11

2018 6

2017 13

2016 7

2015 18

2014 21

2013 6

2012 6

2011 7

2010 7

2009 9

2008 4

2007 6

2006 9

2005 2

2004 2

展开︾

关键词

热释放速率 3

剖宫产瘢痕妊娠 2

治疗 2

火灾 2

1)模型 1

BNCT医院中子照射器 1

CO₂ 捕集 1

COVID-19 1

GDP 1

GDP年增长率 1

GM(1 1

HCG日 1

HIV感染孕产妇 1

IEEE 802-16e 1

IVF/ICSI 新鲜周期 1

PVC火 1

QoS 1

TBM 1

TORCH 1

展开︾

检索范围：

排序：展示方式：

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

《医学前沿（英文）》 2017年第11卷第4期页码 563-569 doi: 10.1007/s11684-017-0535-6

摘要：

The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79–1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78–1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.

关键词： blastocyst embryo transfer cumulative pregnancy rate cumulative live birth rate IVF

HTML PDF 收藏

免费孕前优生健康检查对象潜在危险因素接触和妊娠结局分析

车焱,周公望,王彩琴,张焕玲,张建娥,闫立新,陆珍,陆梅,沈洁,朱昊平

《中国工程科学》 2014年第16卷第5期页码 56-59

摘要：

分析并报告上海市静安区免费孕前优生健康检查后待孕夫妇不良妊娠结局潜在影响因素接触情况以及妊娠率和妊娠结局，为免费孕前健康检查政府实施项目效果的评估提供基础数据。对2011 年8 月—2012 年11 月在静安区参加免费孕前优生健康检查的所有对象在其检查结束后的3 个月、6 个月、12 个月进行随访，重点关注不良妊娠结局潜在危险因素接触情况以及妊娠时间和妊娠结局。统计方法为χ2检验、寿命表、Logistic 回归分析。在目标时段内共有1 480 对夫妇参加了免费孕前优生健康检查，其中1 249 对服务对象接受了随访，随访率为84.4 %。截至2013 年4 月，48.7 %的随访对象已经受孕，孕前检查后3 个月调查累积妊娠率为23.9 %，6 个月调查累积妊娠率为45.0 %。365 人完成妊娠结局的随访，结果显示，早产率为3.0 %，低出生体重率为4.3 %，巨大儿发生率为3.3 %。自然流产率为6.3 %。另外，发现出生缺陷1 人，占妊娠妇女数的0.16 %，占有妊娠结局妇女数的0.27 %。烟酒等不良生活习惯丈夫的比例（18 %～20 %）高于妻子（1 %～3 %），77 %的丈夫和妻子接受潜在电磁辐射的时间超过8 h。9 %的夫妇自述生活和工作中接触重金属以及农药、化肥等潜在致畸物。超过10 %的妻子在怀孕以后接触了潜在致畸物。初步分析未发现上述因素与不良妊娠结局的关系。静安区孕前健康检查后半年内妇女妊娠率不到50 %，有必要在上海乃至全国开展免费孕前健康检查的成本效益评估。

关键词：孕前优生健康检查妊娠率累积妊娠率不良妊娠结局危险因素

HTML PDF 收藏

HCG注射日血清雌孕激素对试管婴儿妊娠结局的影响

周丹妮,杨菁,吴庚香,李赛姣,余楠,赵萌,文妍琪

《中国工程科学》 2014年第16卷第5期页码 79-84

摘要：

探究体外受精—胚胎移植/单精子卵泡浆内注射-胚胎移植（IVF/ICSI）患者注射人绒毛膜促性腺激素（HCG）日血清雌孕激素水平对妊娠结局的影响。回顾分析武汉大学人民医院生殖医学中心2011 年9 月—2012 年9 月符合相关条件行IVF的新鲜周期患者1 270 例，按血清孕酮值将其分为两组进行比较，低孕酮组HCG日血清孕酮值<2.0 pg/mL，高孕酮组HCG日血清孕酮值≥2.0 pg/mL；再按照孕酮与雌二醇比值（P/E2）分为两组，以0.6 作为P/E2切点。比较两组间的女方年龄、不孕年限、基础卵泡刺激素（FSH）值、促性腺激素（Gn）天数、Gn用量、获卵数、MII 卵数、受精数、卵裂数、优胚数、移植数、E2值、临床妊娠率、胚胎着床率。高孕酮组Gn天数、Gn用量、获卵数、MII数、卵裂数、E2值增加，但临床妊娠率、胚胎着床率减少；高P/E2比值组女方年龄、基础FSH、Gn 天数、Gn 用量、获卵数、受精数、优胚数、P 值均增加，妊娠结局无明显差异。HCG注射日血清孕酮水平过高会降低临床妊娠率及胚胎着床率。

关键词：孕酮值 HCG日 IVF/ICSI 新鲜周期临床妊娠率

HTML PDF 收藏

广州市2 046例孕前育龄妇女TORCH检查状况分析

余志衡

《中国工程科学》 2014年第16卷第5期页码 63-66

摘要：

采用酶联免疫吸附试验(ELISA) 对2013 年1 月—2013 年12 月进行孕前筛查和孕早期普查的2 046 例妇女进行TORCH 特异性IgM 和IgG 抗体检测，主要检测RV-IgG、TOXO-IgG、TOXO-IgM、CMVIgG、CMV-IgM 五项。在调查的2 046 例妇女中，TORCH-IgM 总阳性率为0. 88 %，其中以巨细胞病毒(CMV)感染率居高，为0.68%，弓形虫（TOXO）为0. 20%。TORCH－IgG 阳性率以CMV最高，达97.65 %，其次为RV-IgG、TOXO-IgG，分别为85.58 %和4.89 %。广州市孕前和孕早期妇女TORCH感染率较高，应该积极进行监测和宣传，早发现，早干预，提高出生人口素质，减少出生缺陷与残疾发生。

关键词： TORCH 感染率酶联免疫吸附试验出生缺陷孕前检查

HTML PDF 收藏

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

《医学前沿（英文）》 2023年第17卷第3期页码 549-561 doi: 10.1007/s11684-022-0965-7

摘要： Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

关键词： pregnancy IgG glycome type I interferon systemic lupus erythematosus

HTML PDF 收藏

青藏高原多年冻土地带爆破研究

何广沂

《中国工程科学》 2001年第3卷第6期页码 57-64

摘要：

介绍了青藏高原多年冻土地带铁路试验工程中有关爆破方面的研究成果，针对多年冻土的特征，重点论述了爆破方法与工艺及先进实用的聚能爆破技术。

关键词：多年冻土路堑基坑钻孔聚能弹聚能爆破

HTML PDF 收藏

Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis

Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin

《医学前沿（英文）》 2019年第13卷第1期页码 121-125 doi: 10.1007/s11684-018-0615-2

摘要： This retrospective study aims to demonstrate the effect of antitubercular treatment (ATT) on the pregnancy outcomes and prognoses of patients with genital tuberculosis (GTB) who had received laparoscopy and/or hysteroscopy. This study included 78 patients with infertility and who were diagnosed with GTB through laparoscopy and/or hysteroscopy over the period of November 2005 to October 2015. The recruited patients were divided into ATT and nonATT groups on the basis of ATT duration. The GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined at follow-up. Among the 78 patients, 46 received ATT and 32 did not receive ATT. The menstrual volumes of patients in the ATT group significantly decreased relative to those of patients in the nonATT group. GTB did not recur among all patients regardless of treatment. A total of 11 pregnancies (36.7%) in the ATT group and 19 pregnancies (63.3%) in the nonATT group were observed. Pregnancy rates significantly differed ( = 0.002) between the two groups. ATT may decrease the menstrual volume and pregnancy rates of patients who were diagnosed with GTB through laparoscopy and/or hysteroscopy. In addition, ATT did not improve the prognosis of patients with chronic GTB.

关键词： antitubercular treatment pregnancy prognosis genital tuberculosis

HTML PDF 收藏

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

null

《医学前沿（英文）》 2015年第9卷第3期页码 380-383 doi: 10.1007/s11684-015-0407-x

摘要：

Cushing’s syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal complications. A case of CS during the third trimester of pregnancy secondary to adrenocortical adenoma was reported. Literature review revealed the disadvantages of different treatments in this period. Besides the conservative treatment, surgery is recommended for CS during the third trimester of pregnancy secondary to adrenal adenoma, if an experienced surgeon is available.

关键词： Cushing’s syndrome pregnancy adrenocortical adenoma

HTML PDF 收藏

一项关于药物和补充剂对改善男性不育症患者的自然妊娠和精液参数影响的系统综述和网状荟萃分析 Article

李建, 吴奇, Ernest Hung Yu Ng, Ben Willem J. Mol, 吴效科, Chi Chiu Wang

《工程（英文）》 2022年第16卷第9期页码 198-209 doi: 10.1016/j.eng.2021.07.009

摘要：

本研究采用网状荟萃分析对药物和补充剂治疗特发性男性不育症的疗效进行比较，以获得最佳治疗方法。对Medline、EMBASE、OVID和CNKI等数据库中发表于1990年1月至2021年6月的文献进行检索，检索关键词包括“男性不育”“药物疗法”“补充/营养疗法”及其相关术语等。将研究药物[主要包括促卵泡激素（FSH）、雄激素、克罗米芬/他莫昔芬（SERM）]或补充剂[主要是锌、硒、维生素C/E、卡尼丁、辅酶Q₁₀（CoQ₁₀）或联合治疗]治疗特发性不育男性的随机对照试验（RCT）纳入meta分析。按PRISMA声明中的报告规范提取数据，并使用偏倚风险工具和适用于网状meta分析的GRADE系统评估证据质量。研究的主要结局是活产率和自然妊娠率（SPR），次要结局是精子参数（包括精子浓度、前向运动百分比和形态）和不良反应。65项RCT被纳入分析，共包括7541名精子参数异常但激素水平正常的育龄男性。36项研究报道SPR，但仅三项研究报道活产率。纳入研究的质量评价为中、高级。与安慰剂或未治疗相比，卡尼汀联合维生素治疗显著增加SPR（RR = 3.7, 95% CI为1.6 ~ 8.5），脂肪酸补充剂显著增加精子浓度（MD = 12.5 × 10⁶ mL^–1, 95% CI为3.1 × 10⁶ ~ 22.0 × 10⁶）。SERM联合辅酶Q₁₀显著提升前向活力精子（MD = 11.0%, 95% CI为0.1% ~ 21.9%）和正常形态精子（MD = 11.0%, 95% CI为4.6% ~ 17.4%）。对改善SPR和精子浓度的最佳治疗方案分别是卡尼汀联合维生素和脂肪酸补充剂，即便排除具有高偏倚风险的研究，结果仍保持一致。对于少弱精子症男性，与安慰剂或未治疗相比，FSH（RR = 4.9, 95% CI为1.1 ~ 21.3）显著增加SPR，而SERM联合激肽酶可显著增加精子浓度（MD = 16.5 × 10⁶ mL^–1, 95% CI为1.6 × 10⁶ ~ 31.4 × 10⁶)，SERM联合辅酶Q₁₀则显著改善前向活力精子（MD = 11.3%, 95% CI为7.3% ~ 15.4%）和正常形态精子（MD = 11.2%, 95% CI为 5.4% ~ 16.9%）。在不良反应方面，脂肪酸补充剂和己酮可可碱分别与口臭或味觉差（RR = 8.1, 95% CI为1.0 ~ 63.5）和呕吐（RR = 8.0, 95% CI为1.0 ~ 63.0）相关。综上所述，对于改善不育男性配偶活产率的最佳治疗方案仍然不清楚。对于所有不孕夫妇和男性少弱精症不孕夫妇，卡尼汀联合维生素和FSH方案在成功实现自然妊娠方面分别优于其他方案。其他治疗方法对妊娠结局的疗效仍需要进一步验证。

关键词：男性不育症药物补充剂自然妊娠率精子参数

HTML PDF 收藏

The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

《农业科学与工程前沿（英文）》 2016年第3卷第2期页码 147-152 doi: 10.15302/J-FASE-2016099

摘要： In cows, progesterone (P4) is essential for the maintenance of pregnancy and successful embryo development is dependent on the maternal immunomodulation of Th-related cytokines. However, investigation of the relationship between P4 and Th immunity in cattle remains incomplete. Therefore, we evaluated plasma P4 concentrations and expressions of three Th-related cytokines, interleukins IL-1β, IL-4 and IL-6, in 15 pregnant and 11 non-pregnant cows 0, 14, 18, 21, and 28 d post artificial insemination. Pregnant cows had significantly higher plasma P4 levels and pregnant cows with higher P4 on 14 d tended to have higher P4 in the subsequent period of pregnancy. There was no difference in IL-4 and IL-6 expression between pregnant cows and non-pregnant cows, whereas plasma IL-1β was temporally upregulated on 21 d. The cytokines measured were not affected in either the high-P4 group (>11.1 ng·mL ) or the low-P4 group (<11.1 ng·mL ) in pregnant cows. A weak negative correlation between IL-1β and IL-6 was observed, but none of the cytokines was associated with a change in plasma P4. In conclusion, there was no clear relationship between P4 and Th immunity in maternal plasma in the pregnant cows, which differs from what occurs in humans and mice during early pregnancy.

关键词： dairy cow progesterone pregnancy cytokine

HTML PDF 收藏

Nonlinear cumulative damage model for multiaxial fatigue

SHANG De-guang, SUN Guo-qin, DENG Jing, YAN Chu-liang

《机械工程前沿（英文）》 2006年第1卷第3期页码 265-269 doi: 10.1007/s11465-006-0035-x

摘要： On the basis of the continuum fatigue damage theory, a nonlinear uniaxial fatigue cumulative damage model is first proposed. In order to describe multiaxial fatigue damage characteristics, a nonlinear multiaxial fatigue cumulative damage model is developed based on the critical plane approach. The proposed model can consider the multiaxial fatigue limit, mean hydrostatic pressure and the unseparated characteristic for the damage variables and loading parameters. The recurrence formula of fatigue damage model was derived under multilevel loading, which is used to predict multiaxial fatigue life. The results showed that the proposed nonlinear multiaxial fatigue cumulative damage model is better than Miner s rule.

HTML PDF 收藏

displacement caused by seismic liquefaction and performing parametric sensitivity analysis: Considering cumulative

Nima PIRHADI, Xiaowei TANG, Qing YANG, Afshin ASADI, Hazem Samih MOHAMED

《结构与土木工程前沿（英文）》 2021年第15卷第2期页码 506-519 doi: 10.1007/s11709-021-0677-0

摘要： Lateral displacement due to liquefaction ( ) is the most destructive effect of earthquakes in saturated loose or semi-loose sandy soil. Among all earthquake parameters, the standardized cumulative absolute velocity ( ) exhibits the largest correlation with increasing pore water pressure and liquefaction. Furthermore, the complex effect o fine content( ) at different values has been studied and demonstrated. Nevertheless, these two contexts have not been entered into empirical and semi-empirical models to predict This study bridges this gap by adding to the data set and developing two artificial neural network (ANN) models. The first model is based on the entire range of the parameters, whereas the second model is based on the samples with values that are less than the 28% critical value. The results demonstrate the higher accuracy of the second model that is developed even with less data. Additionally, according to the uncertainties in the geotechnical and earthquake parameters, sensitivity analysis was performed via Monte Carlo simulation (MCS) using the second developed ANN model that exhibited higher accuracy. The results demonstrated the significant influence of the uncertainties of earthquake parameters on predicting

关键词： lateral spreading displacement cumulative absolute velocity fine content artificial neural network sensitivity analysis Monte Carlo simulation

HTML PDF 收藏

继发性中晚期腹腔妊娠诊断和治疗 ——附一例病例报道

申颖,戴姝艳

《中国工程科学》 2015年第17卷第6期页码 61-64

摘要：

目的：探讨继发性中晚期腹腔妊娠的诊断以及治疗方案。方法：回顾性地分析和总结我院收治的1例继发性中晚期腹腔妊娠的诊断及治疗方案。结果：该病例经磁共振成像（MRI）检查明确诊断，同时成功予以手术治疗。结论：继发性中晚期腹腔妊娠非常罕见，临床症状不典型，早期诊断较困难，MRI是一种有效的诊断方法，手术是最重要的治疗方式。

关键词：腹腔妊娠诊断治疗磁共振成像

HTML PDF 收藏

确定性疲劳累积损伤理论进展

杨晓华,姚卫星,段成美

《中国工程科学》 2003年第5卷第4期页码 81-87

摘要：

著名的Miner-Palmgren线性累积损伤理论的提出已有70余年，但由于疲劳问题的复杂性，迄今为止还没有一个模型的工程应用价值能与该理论媲美。疲劳累积损伤理论仍在发展与完善中。文章根据疲劳损伤与疲劳累积损伤理论的特点，将确定性疲劳累积损伤理论分成两大类，即线性累积损伤理论和非线性累积损伤理论，并将主要的非线性累积损伤理论分成五类：a. 基于损伤曲线法的非线性累积损伤理论；b. 基于材料物理性能退化概念的非线性累积损伤理论；c. 基于连续损伤力学概念的非线性累积损伤理论；d. 考虑载荷间相互作用效应的非线性累积损伤理论；e. 基于能量法的非线性累积损伤理论。文章分析了每一类模型中有代表性模型的物理背景，回答了模型在疲劳累积损伤理论中存在的主要问题，简要评述了模型的优缺点，讨论了确定性疲劳累积损伤理论的几个关键问题。

关键词：疲劳线性与非线性累积损伤损伤力学能量

HTML PDF 收藏

An update and cumulative meta-analysis

null

《医学前沿（英文）》 2014年第8卷第2期页码 241-249 doi: 10.1007/s11684-014-0328-0

摘要：

Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.

关键词： non-muscle invasive bladder cancer bacillus Calmette-Guérin (BCG) meta-analysis